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Cellosaurus BRG-M (CVCL_W882)

[Text version]
Cell line name BRG-M
Synonyms BRG M; BRG IgM; BRG-IgM; BRG-P.1
Accession CVCL_W882
Resource Identification Initiative To cite this cell line use: BRG-M (RRID:CVCL_W882)
Comments Population: Caucasian.
Characteristics: IgM producing subclone of BRG-P.
Virology: EBV-negative.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg158His (c.473G>A); ClinVar=VCV000141963; Zygosity=Heterozygous (PubMed=9399658).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu286Gly (c.857_858AA>GT); Zygosity=Heterozygous (PubMed=9399658).
Disease Burkitt lymphoma (NCIt: C2912)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_W880 (BRG-P)
Children:
CVCL_UI47 (BRG-H)
Sex of cell Female
Age at sampling 30Y
Category Cancer cell line
Publications

PubMed=8207254; DOI=10.4049/jimmunol.153.1.45
Jain R., Roncella S., Hashimoto S., Carbone A., Francia di Celle P., Foa R., Ferrarini M., Chiorazzi N.
A potential role for antigen selection in the clonal evolution of Burkitt's lymphoma.
J. Immunol. 153:45-52(1994)

PubMed=8695808; DOI=10.1182/blood.V88.2.599.bloodjournal882599
Roncella S., Cutrona G., Favre A., Ulivi M., Fais F., Signorini A., Grossi C.E., Chiorazzi N., Ferrarini M.
Apoptosis of Burkitt's lymphoma cells induced by specific interaction of surface IgM with a self-antigen: implications for lymphomagenesis in acquired immunodeficiency syndrome.
Blood 88:599-608(1996)

PubMed=9399658; DOI=10.1002/(SICI)1097-0215(19971210)73:6<816::AID-IJC8>3.0.CO;2-5
Campomenosi P., Fronza G., Ottaggio L., Roncella S., Inga A., Bogliolo M., Monti P., Assereto P., Moro F., Cutrona G., Bozzo S., Chiorazzi N., Abbondandolo A., Ferrarini M.
Heterogeneous p53 mutations in a Burkitt lymphoma from an AIDS patient with monoclonal c-myc and VDJ rearrangements.
Int. J. Cancer 73:816-821(1997)

PubMed=10702812
Zunino A., Viaggi S., Ottaggio L., Fronza G., Schenone A., Roncella S., Abbondandolo A.
Chromosomal aberrations evaluated by CGH, FISH and GTG-banding in a case of AIDS-related Burkitt's lymphoma.
Haematologica 85:250-255(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_W882
Encyclopedic resources Wikidata; Q54798229
Polymorphism and mutation databases Cosmic; 1515196
IARC_TP53; 6585
Entry history
Entry creation17-Jul-2014
Last entry update05-Oct-2023
Version number13