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Cellosaurus REPC (CVCL_W815)

[Text version]
Cell line name REPC
Synonyms Renal EPO-Producing Cells
Accession CVCL_W815
Resource Identification Initiative To cite this cell line use: REPC (RRID:CVCL_W815)
Comments Problematic cell line: Contaminated. Shown to be a Hep 3B2.1-7 derivative. Original paper (PubMed=21406725) has been retracted.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00487.
Population: African American.
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Caution: 10.1182/blood-2014-04-571752 is a retractation of PubMed=21406725.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 903; AXIN1; Simple; p.Arg146Ter (c.436C>T); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Ser576Ter (c.1727C>G); Zygosity=Homozygous (from parent cell line).
Disease Childhood hepatocellular carcinoma (NCIt: C7955)
Pediatric hepatocellular carcinoma (ORDO: Orphanet_33402)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0326 (Hep 3B2.1-7)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
Web pages https://retractionwatch.com/2014/04/29/contaminated-cells-force-retraction-of-blood-paper/

PubMed=21406725; DOI=10.1182/blood-2010-07-298083
Frede S., Freitag P., Geuting L., Konietzny R., Fandrey J.
Oxygen-regulated expression of the erythropoietin gene in the human renal cell line REPC.
Blood 117:4905-4914(2011)

Frede S., Freitag P., Geuting L., Konietzny R., Fandrey J.
Blood 123:3365-3365(2014)

Biological sample resources BioSample; SAMN03151768
Encyclopedic resources Wikidata; Q54949755
Entry history
Entry creation17-Jul-2014
Last entry update29-Jun-2023
Version number19