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Cellosaurus PC-53 (CVCL_W802)

[Text version]
Cell line name PC-53
Synonyms PC53
Accession CVCL_W802
Resource Identification Initiative To cite this cell line use: PC-53 (RRID:CVCL_W802)
Comments Characteristics: Established at the 3rd relapse.
Doubling time: 70-80 hours (PubMed=2314113).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=34940123).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=34940123).
  • Gene fusion; HGNC; HGNC:8017; NSMAF + HGNC; HGNC:29923; NUCKS1; Name(s)=NSMAF-NUCKS1; Note=NSMAF exon 1/NUCKS1 exon 2 fusion (PubMed=34940123).
  • Mutation; HGNC; HGNC:8619; PAX5; Simple; p.Arg38His (c.113G>A); Zygosity=Heterozygous (PubMed=34940123).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_W803 ! PC-53A
Sex of cell Female
Age at sampling 33Y
Category Cancer cell line
Publications

PubMed=2314113; DOI=10.1016/0145-2126(90)90047-D
Tarella C., Pregno P., Gallo E., Caracciolo D., Stefani S., Barletta C., Lanfrancone L., Ferrero D.
Establishment from an adult leukemic patient of two novel precursor B cell lines with different growth modality.
Leuk. Res. 14:177-184(1990)

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Uphoff C.C., MacLeod R.A.F., Denkmann S.A., Golub T.R., Borkhardt A., Janssen J.W.G., Drexler H.G.
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=34940123; DOI=10.3390/cimb43030149; PMCID=PMC8929001
Quentmeier H., Pommerenke C., Drexler H.G.
Molecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression.
Curr. Issues Mol. Biol. 43:2147-2156(2021)

Cross-references
Encyclopedic resources Wikidata; Q54938459
Gene expression databases ArrayExpress; E-MTAB-11038
ArrayExpress; E-MTAB-11039
Polymorphism and mutation databases Cosmic; 2491090
Entry history
Entry creation17-Jul-2014
Last entry update10-Apr-2025
Version number12