| Cell line name |
PC-53 |
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| Synonyms |
PC53 |
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| Accession |
CVCL_W802 |
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| Resource Identification Initiative |
To cite this cell line use: PC-53 (RRID:CVCL_W802) |
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| Comments |
Characteristics: Established at the 3rd relapse.
Doubling time: 70-80 hours (PubMed=2314113).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=34940123).
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=34940123).
- Gene fusion; HGNC; HGNC:8017; NSMAF + HGNC; HGNC:29923; NUCKS1; Name(s)=NSMAF-NUCKS1; Note=NSMAF exon 1/NUCKS1 exon 2 fusion (PubMed=34940123).
- Mutation; HGNC; HGNC:8619; PAX5; Simple; p.Arg38His (c.113G>A); Zygosity=Heterozygous (PubMed=34940123).
|
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| Disease |
Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Originate from same individual |
CVCL_W803 ! PC-53A |
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| Sex of cell |
Female |
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| Age at sampling |
33Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=2314113; DOI=10.1016/0145-2126(90)90047-D
Corrado Tarella, Patrizia Pregno, Eugenio Gallo, Daniele Caracciolo, Silvia Stefani, Cosimo Barletta, Luisa Lanfrancone, Dario Ferrero;
Establishment from an adult leukemic patient of two novel precursor B cell lines with different growth modality.
Leuk. Res. 14:177-184(1990) PubMed=9067587; DOI=10.1038/sj.leu.2400571
Cord C. Uphoff, Roderick A.F. MacLeod, Sabine A. Denkmann, Todd Robert Golub, Arndt Borkhardt, Johannes W.G. Janssen, Hans Gunther Drexler;
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997) DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001) PubMed=34940123; DOI=10.3390/cimb43030149; PMCID=PMC8929001
Hilmar Quentmeier, Claudia Pommerenke, Hans Gunther Drexler;
Molecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression.
Curr. Issues Mol. Biol. 43:2147-2156(2021) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q54938459
|
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| Gene expression databases |
ArrayExpress; E-MTAB-11038
ArrayExpress; E-MTAB-11039
|
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| Polymorphism and mutation databases |
Cosmic; 2491090
|
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| Entry history |
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| Entry creation | 17-Jul-2014 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 12 |
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