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Cellosaurus HUES 71 (CVCL_W717)

[Text version]
Cell line name HUES 71
Synonyms HUES71; HuES71
Accession CVCL_W717
Resource Identification Initiative To cite this cell line use: HUES 71 (RRID:CVCL_W717)
Comments From: Harvard University; Boston; USA.
Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-14-0281.
Omics: Genomics; Whole exome sequencing.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Blastocyst stage
Category Embryonic stem cell
Publications

PubMed=28445466; DOI=10.1038/nature22312; PMCID=PMC5427175
Florian T. Merkle, Sulagna Ghosh, Nolan Kamitaki, Jana Mitchell, Yishai Avior, Curtis Mello, Seva Kashin, Shila Mekhoubad, Dusko Ilic, Maura Charlton, Genevieve Saphier ...Show all 17 authors... , Robert E. Handsaker, Giulio Genovese, Shiran Bar, Nissim Benvenisty, Steven A. McCarroll, Kevin Carl Eggan; Show fewer authors
Human pluripotent stem cells recurrently acquire and expand dominant negative p53 mutations.
Nature 545:229-233(2017)

Cross-references
Cell line databases/resources NIHhESC; NIHhESC-14-0281
Encyclopedic resources Wikidata; Q54896814
Entry history
Entry creation16-Apr-2014
Last entry update10-Apr-2025
Version number15