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Cellosaurus NB4-D5 (CVCL_VV79)

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Cell line name NB4-D5
Synonyms NB4D5
Accession CVCL_VV79
Resource Identification Initiative To cite this cell line use: NB4-D5 (RRID:CVCL_VV79)
Comments Population: Caucasian.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (PubMed=8839862).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0005 (NB4)
Children:
CVCL_VV80 (NB4-MR2)CVCL_VV81 (NB4-MR6)CVCL_VV82 (NB4-R4)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line
Publications

PubMed=8839862; DOI=10.1182/blood.V88.7.2671.bloodjournal8872671
Angelika Rosenauer, John Verner Raelson, Clara Nervi, Patrice Eydoux, Anthony DeBlasio, Wilson H. Miller Jr.;
Alterations in expression, binding to ligand and DNA, and transcriptional activity of rearranged and wild-type retinoid receptors in retinoid-resistant acute promyelocytic leukemia cell lines.
Blood 88:2671-2682(1996)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VV79
Encyclopedic resources Wikidata; Q95992300
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number11