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Cellosaurus NB4-B1 (CVCL_VV78)

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Cell line name NB4-B1
Accession CVCL_VV78
Resource Identification Initiative To cite this cell line use: NB4-B1 (RRID:CVCL_VV78)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_15367; All-trans-retinoic acid (ATRA; Tretinoin).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (PubMed=12353268).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0005 (NB4)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line
Publications

PubMed=12353268; DOI=10.1002/gcc.10117
Marie-Joelle Mozziconacci, Angelika Rosenauer, Audrey Restouin, Mirco Fanelli, Wen-Lin Shao, Francisca Fernandez, Yves Toiron, Jeanine Viscardi, Carlo Gambacorti-Passerini, Wilson H. Miller Jr., Marina Lafage-Pochitaloff;
Molecular cytogenetics of the acute promyelocytic leukemia-derived cell line NB4 and of four all-trans retinoic acid-resistant subclones.
Genes Chromosomes Cancer 35:261-270(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VV78
Encyclopedic resources Wikidata; Q95992298
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number11