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Cellosaurus SCCOHT-1 (CVCL_VU69)

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Cell line name SCCOHT-1
Synonyms SCCOHT1; Small Cell Carcinoma of the Ovary, Hypercalcemic Type-1
Accession CVCL_VU69
Resource Identification Initiative To cite this cell line use: SCCOHT-1 (RRID:CVCL_VU69)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 38.1 hours (PubMed=22581215).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:11100; SMARCA4; Simple; p.Arg1077Ter (c.3229C>T); ClinVar=VCV001692588; Zygosity=Heterozygous (DepMap=ACH-001279).
Disease Ovarian small cell carcinoma, hypercalcemic type (NCIt: C40439)
Small cell carcinoma of the ovary (ORDO: Orphanet_370396)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 31Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC437

Markers:
AmelogeninX
CSF1PO10,11
D3S135815,17
D5S81811,12
D7S82010,11
D8S117913,14
D13S3178,12
D16S5399,13
D18S5113
D21S1128,31.2
FGA16,25
Penta D12,15
Penta E10,13
TH017,8
TPOX8,9
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=22581215; DOI=10.3892/ijo.2012.1468
Anna Otte, Gudrun Gohring, Doris Steinemann, Brigitte Schlegelberger, Stephanie Groos, Florian Langer, Hans-Heinrich Kreipe, Axel Schambach, Thomas Neumann, Peter Hillemanns, Tjoung-Won Park-Simon, Ralf Hass;
A tumor-derived population (SCCOHT-1) as cellular model for a small cell ovarian carcinoma of the hypercalcemic type.
Int. J. Oncol. 41:765-775(2012)

PubMed=26356327; DOI=10.1002/path.4633; PMCID=PMC4832362
Anthony N. Karnezis, Ye-Min Wang, Pilar Ramos, William P.D. Hendricks, Esther Oliva, Emanuela D'Angelo, Jaime Prat, Marisa Rose Nucci, Torsten O. Nielsen, Christine Chow, Samuel Leung ...Show all 21 authors... , Friedrich Kommoss, Stefan Kommoss, Annacarolina Silva, Brigitte M. Ronnett, Joseph T. Rabban 3rd, David D.L. Bowtell, Bernard E. Weissman, Jeffrey M. Trent, Cyril Blake Gilks, David G. Huntsman; Show fewer authors
Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.
J. Pathol. 238:389-400(2016)

Cross-references
Cell line collections (Providers) Millipore; SCC437
Cell line databases/resources cancercelllines; CVCL_VU69
Cell_Model_Passport; SIDM01866
DepMap; ACH-001279
Anatomy/cell type resources BTO; BTO_0005853
Encyclopedic resources Wikidata; Q98129384
Gene expression databases GEO; GSM1622408
GEO; GSM2748144
GEO; GSM2748145
GEO; GSM2748146
GEO; GSM2748147
GEO; GSM2748148
GEO; GSM2748149
Entry history
Entry creation24-May-2019
Last entry update10-Apr-2025
Version number15