Cellosaurus logo
expasy logo

Cellosaurus CHM13hTERT (CVCL_VU12)

[Text version]
Cell line name CHM13hTERT
Synonyms CHM13htert; CHM13
Accession CVCL_VU12
Resource Identification Initiative To cite this cell line use: CHM13hTERT (RRID:CVCL_VU12)
Comments Characteristics: Has a completely homozygous genome, thus representing a functionally haploid genome.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Omics: Genomics; Whole genome sequencing.
Anecdotal: Because of its homozygous genome it is being used to build/correct new generation of human genome assemblies.
Cell type: Fibroblast; CL=CL_0000057.
Disease Hydatidiform mole (NCIt: C3110)
Hydatidiform mole (ORDO: Orphanet_99927)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Fetus
Category Telomerase immortalized cell line
Web pages Info; -; -; https://sites.google.com/ucsc.edu/t2tworkinggroup/chm13-cell-line
Info; diArk; -; https://www.diark.org/diark/species_list/Homo_sapiens_CHM13htert
Publications

PubMed=27895111; DOI=10.1101/gr.214007.116; PMCID=PMC5411763
John Lawton Huddleston, Mark J.P. Chaisson, Karyn Meltz Steinberg, Wesley C. Warren, Kendra Hoekzema, David Gordon, Tina A. Graves-Lindsay, Katherine M. Munson, Zev N. Kronenberg, Laura Vives, Paul Peluso ...Show all 16 authors... , Matthew Boitano, Chen-Shin Chin, Jonas Korlach, Richard K. Wilson, Evan E. Eichler; Show fewer authors
Discovery and genotyping of structural variation from long-read haploid genome sequence data.
Genome Res. 27:677-685(2017)

PubMed=28396521; DOI=10.1101/gr.213611.116; PMCID=PMC5411779
Valerie A. Schneider, Tina A. Graves-Lindsay, Kerstin Howe, Nathan Bouk, Hsiu-Chuan Chen, Paul A. Kitts, Terence D. Murphy, Kim Dixon Pruitt, Francoise Thibaud-Nissen, Derek Albracht, Robert S. Fulton ...Show all 38 authors... , Milinn Kremitzki, Vincent Magrini, Chris Markovic, Sean McGrath, Karyn Meltz Steinberg, Kate Auger, William Chow, Joanna Collins, Glenn Harden, Timothy John Phillip Hubbard, Sarah Pelan, Jared T. Simpson, Glen Threadgold, James Torrance, Jonathan M. Wood, Laura Clarke, Sergey Koren, Matthew Boitano, Paul Peluso, Heng Li, Chen-Shan Chin, Adam M. Phillippy, Richard Durbin, Richard K. Wilson, Paul Flicek, Evan E. Eichler, Deanna M. Church; Show fewer authors
Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly.
Genome Res. 27:849-864(2017)

PubMed=30013044; DOI=10.1038/s41592-018-0054-7; PMCID=PMC6341484
Heng Li, Jonathan M. Bloom, Yossi Farjoun, Mark Fleharty, Laura Gauthier, Benjamin Michael Neale, Daniel G. MacArthur;
A synthetic-diploid benchmark for accurate variant-calling evaluation.
Nat. Methods 15:595-597(2018)

PubMed=32663838; DOI=10.1038/s41586-020-2547-7; PMCID=PMC7484160
Karen Hayden Miga, Sergey Koren, Arang Rhie, Mitchell Robert Vollger, Ariel Gershman, Andrey V. Bzikadze, Shelise Y. Brooks, Edmund Howe, David Porubsky, Glennis Amelia Logsdon, Valerie A. Schneider ...Show all 53 authors... , Tamara A. Potapova, Jonathan M. Wood, William Chow, Joel Armstrong, Jeanne Fredrickson, Evgenia Pak, Kristof Tigyi, Milinn Kremitzki, Christopher Markovic, Valerie Maduro, Amalia Dutra, Gerard G. Bouffard, Alexander M. Chang, Nancy F. Hansen, Amy B. Wilfert, Francoise Thibaud-Nissen, Anthony D. Schmitt, Jon-Matthew Belton, Siddarth Selvaraj, Megan Y. Dennis, Daniela C. Soto, Ruta Sahasrabudhe, Gulhan Kaya, Josh Quick, Nicholas James Loman, Nadine Holmes, Matthew William Loose, Urvashi Surti, Rosa Ana Risques, Tina A. Graves-Lindsay, Robert S. Fulton, Ira M. Hall, Benedict Paten, Kerstin Howe, Winston Timp, Alice C. Young, James C. Mullikin, Pavel Arkadevich Pevzner, Jennifer L. Gerton, Beth Ann Sullivan, Evan E. Eichler, Adam M. Phillippy; Show fewer authors
Telomere-to-telomere assembly of a complete human X chromosome.
Nature 585:79-84(2020)

Cross-references
Biological sample resources BioSample; SAMN03255769
Encyclopedic resources Wikidata; Q93450973
Entry history
Entry creation24-May-2019
Last entry update10-Apr-2025
Version number7