Cellosaurus cell line Hermes 2B (CVCL

Cellosaurus Hermes 2B (CVCL_VS08)

Cross-references
Cell line name	Hermes 2B
Synonyms	Hermes 2b; Hermes2B; Human extended-replication melanocytes-2B
Accession	CVCL_VS08
Resource Identification Initiative	To cite this cell line use: Hermes 2B (RRID:CVCL_VS08)
Comments	Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Omics: Transcriptomics; Microarray. Omics: Variations; SNP array analysis. Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Melanocyte of skin; CL=CL_1000458.
Sequence variations	Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Met53Thr (c.158T>C); ClinVar=VCV001480737; Zygosity=Heterozygous (PubMed=12759390). Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp108Asn (c.322G>A) (p.Arg122Gln, c.365G>A); ClinVar=VCV000216275; Zygosity=Heterozygous (PubMed=12759390).
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_VS15 (Hmel-p16-2)
Sex of cell	Female
Age at sampling	28Y
Category	Telomerase immortalized cell line
Publications	PubMed=12759390; DOI=10.1093/jnci/95.10.723 Elena V. Sviderskaya, Vanessa C. Gray-Schopfer, Simon P. Hill, Nico P. Smit, Tracy J. Evans-Whipp, Jacquelyn Bond, Lucy Hill, Veronique Bataille, Gordon Peters, David Kipling, David Wynford-Thomas, Dorothy Catherine Bennett; p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression. J. Natl. Cancer Inst. 95:723-732(2003) PubMed=21343389; DOI=10.1158/0008-5472.CAN-10-2958; PMCID=PMC3070783 Amy E. Rose, Laura Poliseno, Jin-Hua Wang, Michael Clark, Alexander Pearlman, Gui-Min Wang, Eleazar Carmelo Vega y Saenz de Miera, Ratna Medicherla, Paul J. Christos, Richard Shapiro, Anna Pavlick ...Show all 17 authors... , Farbod Darvishian, Jiri Zavadil, David Polsky, Eva Hernando, Harry Ostrer, Iman Osman; Show fewer authors Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression. Cancer Res. 71:2561-2571(2011)
Encyclopedic resources	Wikidata; Q94104106
Gene expression databases	GEO; GSM555118 GEO; GSM555170
Entry history
Entry creation	25-Feb-2019
Last entry update	14-Aug-2025
Version number	13