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Cellosaurus Hermes 1 (CVCL_VS06)

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Cell line name Hermes 1
Synonyms Hermes1; Human extended-replication melanocytes-1
Accession CVCL_VS06
Resource Identification Initiative To cite this cell line use: Hermes 1 (RRID:CVCL_VS06)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Melanocyte of skin; CL=CL_1000458.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Ala76Cysfs*64 (c.225_243del19) (p.Arg90Valfs*76, c.268_286del19) (p16-Leiden); ClinVar=VCV000182411; Zygosity=Homozygous (PubMed=12759390).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VS14 (Hmel-p16-1)
Sex of cell Male
Age at sampling 24Y
Category Telomerase immortalized cell line
Publications

PubMed=12759390; DOI=10.1093/jnci/95.10.723
Elena V. Sviderskaya, Vanessa C. Gray-Schopfer, Simon P. Hill, Nico P. Smit, Tracy J. Evans-Whipp, Jacquelyn Bond, Lucy Hill, Veronique Bataille, Gordon Peters, David Kipling, David Wynford-Thomas, Dorothy Catherine Bennett;
p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.
J. Natl. Cancer Inst. 95:723-732(2003)

PubMed=21343389; DOI=10.1158/0008-5472.CAN-10-2958; PMCID=PMC3070783
Amy E. Rose, Laura Poliseno, Jin-Hua Wang, Michael Clark, Alexander Pearlman, Gui-Min Wang, Eleazar Carmelo Vega y Saenz de Miera, Ratna Medicherla, Paul J. Christos, Richard Shapiro, Anna Pavlick ...Show all 17 authors... , Farbod Darvishian, Jiri Zavadil, David Polsky, Eva Hernando, Harry Ostrer, Iman Osman; Show fewer authors
Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.
Cancer Res. 71:2561-2571(2011)

Cross-references
Encyclopedic resources Wikidata; Q94104090
Gene expression databases GEO; GSM555117
GEO; GSM555169
Entry history
Entry creation25-Feb-2019
Last entry update14-Aug-2025
Version number12