Cellosaurus logo
expasy logo

Cellosaurus gMDCKI-MDR1 (CVCL_VR39)

[Text][XML][JSON]
Cell line name gMDCKI-MDR1
Accession CVCL_VR39
Resource Identification Initiative To cite this cell line use: gMDCKI-MDR1 (RRID:CVCL_VR39)
Comments Knockout cell: Method=CRISPR/Cas9; VGNC; VGNC:37431; ABCB1.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:40; ABCB1.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
Hierarchy Parent: CVCL_VR38 (gMDCKI)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=30222362; DOI=10.1021/acs.molpharmaceut.8b00688
Eugene C. Chen, Fabio Broccatelli, Emile Plise, Bu-Yun Chen, Li-Ling Liu, Jonathan Cheong, Shu Zhang, Jamie Jorski, Katherine Gaffney, Kayla K. Umemoto, Laurent Salphati;
Evaluating the utility of canine Mdr1 knockout Madin-Darby canine kidney I cells in permeability screening and efflux substrate determination.
Mol. Pharm. 15:5103-5113(2018)

Cross-references
Encyclopedic resources Wikidata; Q93933962
Entry history
Entry creation13-Nov-2018
Last entry update19-Dec-2024
Version number11