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Cellosaurus SCL60 (CVCL_VQ89)

[Text version]
Cell line name SCL60
Synonyms HEK293[SCL60]; 293-A2
Accession CVCL_VQ89
Resource Identification Initiative To cite this cell line use: SCL60 (RRID:CVCL_VQ89)
Comments Doubling time: 21.4 hours (PubMed=18676858).
Genetic integration: Method=Transfection/transduction; Gene=RGD; 70513; Gnrhr.
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0045 (HEK293)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=7588262; DOI=10.1210/endo.136.11.7588262
Lorraine Anderson, Alison McGregor, Julia V. Cook, Edwin Chilvers, Karin A. Eidne;
Rapid desensitization of GnRH-stimulated intracellular signalling events in alpha T3-1 and HEK-293 cells expressing the GnRH receptor.
Endocrinology 136:5228-5231(1995)

PubMed=18676858; DOI=10.1158/0008-5472.CAN-08-0197
Kevin Morgan, Alan J. Stewart, Nicola Miller, Peter Mullen, Morwenna Muir, Michael Dodds, Federico Medda, David Harrison, Simon P. Langdon, Robert P. Millar;
Gonadotropin-releasing hormone receptor levels and cell context affect tumor cell responses to agonist in vitro and in vivo.
Cancer Res. 68:6331-6340(2008)

CLPUB00443
Colette Meyer;
Characterisation of the direct antiproliferative effects of a gonadotrophin-releasing hormone analogue.
Thesis PhD (2012); University of Edinburgh; Edinburgh; United Kingdom

PubMed=23202794; DOI=10.1530/ERC-12-0192; PMCID=PMC3573841
Colette Meyer, Andrew H. Sims, Kevin Morgan, Beth Harrison, Morwenna Muir, Jia-Ning Bai, Dana Faratian, Robert P. Millar, Simon P. Langdon;
Transcript and protein profiling identifies signaling, growth arrest, apoptosis, and NF-kappaB survival signatures following GNRH receptor activation.
Endocr. Relat. Cancer 20:123-136(2013)

Cross-references
Encyclopedic resources Wikidata; Q98129413
Entry history
Entry creation13-Nov-2018
Last entry update14-Aug-2025
Version number6