Cellosaurus cell line DKAT (CVCL

Cellosaurus DKAT (CVCL_VQ65)

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Cell line name

DKAT

Accession

CVCL_VQ65

Resource Identification Initiative

To cite this cell line use: DKAT (RRID:CVCL_VQ65)

Comments

Group: Patented cell line.
Group: Triple negative breast cancer (TNBC) cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-10322.
Characteristics: Highly tumorigenic. Only 10 DKAT cells are needed to form, in immunocompromised mice, xenograft tumors which display a range of epithelial and mesenchymal phenotypes (PubMed=23049838).
Doubling time: ~24 hours (PubMed=23049838).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (PubMed=23049838).

Disease

Breast carcinoma (NCIt: C4872)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_VQ66 (DKAT-SCGM)

Sex of cell

Female

Age at sampling

35Y

Category

Cancer cell line

Publications

Patent=US20110085982
Victoria Louise Seewaldt, Nicholas C. D'Amato, Julie H. Ostrander;
DKAT cell line, a model for human triple-negative breast cancer.
Patent number US20110085982, 14-Apr-2011

PubMed=23049838; DOI=10.1371/journal.pone.0045684; PMCID=PMC3458110
Nicholas C. D'Amato, Julie H. Ostrander, Michelle L. Bowie, Christopher Sistrunk, Alexander David Borowsky, Robert D. Cardiff, Katie Bell, Lawrence J.T. Young, Karl Simin, Robin Elizabeth Bachelder, Jeffrey J. Delrow ...Show all 17 authors... , Alyssa Dawson, Lisa D. Yee, Krzysztof Mrozek, Timothy M. Clay, Takuya Osada, Victoria Louise Seewaldt; Show fewer authors
Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.
PLoS ONE 7:e45684.1-e45684.17(2012)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_VQ65
Lonza; 1676

Encyclopedic resources

Wikidata; Q93527903

Gene expression databases

GEO; GSM820811
GEO; GSM820812
GEO; GSM820813

Entry history

Entry creation

13-Nov-2018

Last entry update

10-Apr-2025

Version number