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Cellosaurus SKX (CVCL_VP43)

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Cell line name SKX
Accession CVCL_VP43
Resource Identification Initiative To cite this cell line use: SKX (RRID:CVCL_VP43)
Comments Characteristics: Established from a xenograft developed by serial transplantation of the original tumor in nude mice (CelloPub=CLPUB00439).
Characteristics: Defective in double-strand break (DSB) DNA repair. Highly radiosensitive, has a TCD50 value of 19.8 Gy (PubMed=19038467).
Sequence variations
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling 83Y
Category Cancer cell line
Publications

CLPUB00439
Annegret Dorfler, Wolfgang Eicheler, Daniel Zips, Cordula Petersen, Michael Baumann;
Establishment and characterization of a radiation-sensitive squamous cell carcinoma -- SKX -- cell line in vitro.
Exp. Strahlenther. Klin. Strahlenbiol. 9:11-13(2000)

PubMed=11799138; DOI=10.1177/002215540205000207
Wolfgang Eicheler, Daniel Zips, Annegret Dorfler, Reidar Grenman, Michael Baumann;
Splicing mutations in TP53 in human squamous cell carcinoma lines influence immunohistochemical detection.
J. Histochem. Cytochem. 50:197-204(2002)

PubMed=19038467; DOI=10.1016/j.radonc.2008.10.019
Ulla Kasten-Pisula, Apostolos Menegakis, Ingo Brammer, Kerstin Borgmann, Wael Y. Mansour, Sarah Degenhardt, Mechthild Krause, Andreas Schreiber, Jochen Dahm-Daphi, Cordula Petersen, Ekkehard Dikomey, Michael Baumann;
The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair.
Radiother. Oncol. 90:257-264(2009)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VP43
Encyclopedic resources Wikidata; Q98132686
Polymorphism and mutation databases IARC_TP53; 17653
Entry history
Entry creation07-Sep-2018
Last entry update14-Aug-2025
Version number11