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Cellosaurus CFBE41o- 4.7 DeltaF508-CFTR (CVCL_VP35)

[Text version]
Cell line name CFBE41o- 4.7 DeltaF508-CFTR
Synonyms CFBE41oc4-4.7deltaF
Accession CVCL_VP35
Resource Identification Initiative To cite this cell line use: CFBE41o- 4.7 DeltaF508-CFTR (RRID:CVCL_VP35)
Comments Genetic integration: Method=Transfection; Gene=HGNC; HGNC:1884; CFTR (Note=With p.Phe508del (c.1522_1524delTTT)).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSVori-).
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Sequence variations
  • Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Unspecified; Note=In the 2 genomic alleles while the transfected copies are p.Phe508del (c.1522-1524delTTT) (PubMed=18769032).
Disease Cystic fibrosis (NCIt: C2975)
Cystic fibrosis (ORDO: Orphanet_586)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_HL93 (CFBE41o-)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): Millipore=SCC159

Markers:
AmelogeninX
CSF1PO11
D3S135816,18
D5S81811,13
D7S8208,11
D8S117911,14
D13S3179,11
D16S53912
D18S5115,16
D21S1129,31.2
FGA22,24
Penta D12
Penta E12
TH019.3
TPOX8,9
vWA17

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Publications

PubMed=18769032; DOI=10.1159/000149783; PMCID=PMC2927120
Beate Illek, Rosalie Maurisse, Logan Wahler, Karl Kunzelmann, Horst Fischer, Dieter C. Gruenert;
Cl transport in complemented CF bronchial epithelial cells correlates with CFTR mRNA expression levels.
Cell. Physiol. Biochem. 22:57-68(2008)

Cross-references
Cell line collections (Providers) Millipore; SCC159
Encyclopedic resources Wikidata; Q93447380
Entry history
Entry creation07-Sep-2018
Last entry update19-Dec-2024
Version number16