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Cellosaurus HCT 116 BRCA2(-/-) clone 46 (CVCL_VP26)

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Cell line name HCT 116 BRCA2(-/-) clone 46
Synonyms HCT 116 BRCA2 -/- [46]; HCT 116 BRCA2-/-
Accession CVCL_VP26
Resource Identification Initiative To cite this cell line use: HCT 116 BRCA2(-/-) clone 46 (RRID:CVCL_VP26)
Comments Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:1101; BRCA2.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0291 (HCT 116)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): ECACC=18061301

Markers:
AmelogeninX,Y
CSF1PO7,10
D3S135812,19
D5S81810,11
D7S82011,12
D8S117912,13,14
D13S31710,13
D16S53911,13
D18S5116,17
D21S1129,30
FGA18,23
Penta D9,13
Penta E13,14
TH018,9
TPOX8
vWA17,21

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Publications

PubMed=25043256; DOI=10.1002/path.4404; PMCID=PMC4882165
Hong Xu, Jian Xian, Emmanuelle Vire, Steven McKinney, Vivien Wei, Jason Wong, Rebecca Tong, Tony Kouzarides, Carlos Caldas, Samuel Aparicio;
Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells.
J. Pathol. 234:386-397(2014)

Cross-references
Cell line collections (Providers) CancerTools; 153531
ECACC; 18061301 - Discontinued
Ximbio; 153531
Cell line databases/resources cancercelllines; CVCL_VP26
Encyclopedic resources Wikidata; Q93984751
Entry history
Entry creation07-Sep-2018
Last entry update19-Dec-2024
Version number13