Cellosaurus HEK293-HR1 (CVCL_VP07)
| Cell line name | HEK293-HR1 |
|---|---|
| Synonyms | HR1 |
| Accession | CVCL_VP07 |
| Resource Identification Initiative | To cite this cell line use: HEK293-HR1 (RRID:CVCL_VP07) |
| Comments | Characteristics: Expresses the conditional kinase DeltaRaf-1:ER* which consist of the kinase domain of ARAF fused in frame to a modified form of the hormone binding domain of the estrogen receptor (ESR1) that can be de-repressed by 4-hydroxytamoxifen (4-HT) but not beta-estradiol. Genetic integration: Method=Transfection; Gene=HGNC; HGNC:646; ARAF (Note=Kinase domain). Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3467; ESR1 (Note=Ligand-binding domain). Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5. Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113. |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_0045 (HEK293) |
| Sex of cell | Female |
| Age at sampling | Fetus |
| Category | Transformed cell line |
| Publications | PubMed=16513653; DOI=10.1074/jbc.M510275200 |
| Cross-references | |
| Cell line collections (Providers) | CancerTools; 153329
Ximbio; 153329 |
| Encyclopedic resources | Wikidata; Q94095223 |
| Experimental variables resources | EFO; EFO_0022530 |
| Entry history | |
| Entry creation | 07-Sep-2018 |
| Last entry update | 14-Aug-2025 |
| Version number | 9 |