Cellosaurus cell line CUTC60 (CVCL

Cellosaurus CUTC60 (CVCL_VM61)

[Text version]

Cell line name

CUTC60

Accession

CVCL_VM61

Resource Identification Initiative

To cite this cell line use: CUTC60 (RRID:CVCL_VM61)

Comments

Doubling time: 22 hours (PubMed=30733375).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=30733375; PubMed=30737244).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=30733375; PubMed=30737244).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.His193Arg (c.578A>G); ClinVar=VCV000184979; Zygosity=Homozygous (PubMed=30733375; PubMed=30737244).

Disease

Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

59Y

Category

Cancer cell line

STR profile

Source(s): PubMed=30733375; PubMed=30737244

Markers:

Amelogenin	X
CSF1PO	10,12
D3S1358	17,18
D5S818	10,12
D7S820	8
D8S1179	14,16
D13S317	9
D16S539	9,10
D18S51	15
D21S11	32.2
FGA	20
TH01	6,8
TPOX	8,11
vWA	16,18

Publications

PubMed=30733375; DOI=10.1158/1541-7786.MCR-18-1026; PMCID=PMC6711777
Rebecca E. Schweppe, Nikita Pozdeyev, Laura A. Pike, Christopher T. Korch, Qiong Zhou, Sharon B. Sams, Vibha Sharma, Umarani Pugazhenthi, Christopher D. Raeburn, Maria Belen Albuja-Cruz, Philip Reigan ...Show all 16 authors... , Daniel V. LaBarbera, Inigo Landa-Lopez, Jeffrey A. Knauf, James Alexander Fagin, Bryan R. Haugen; Show fewer authors
Establishment and characterization of four novel thyroid cancer cell lines and PDX models expressing the RET/PTC1 rearrangement, BRAFV600E, or RASQ61R as drivers.
Mol. Cancer Res. 17:1036-1048(2019)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_VM61

Encyclopedic resources

Wikidata; Q93460551

Entry history

Entry creation

25-Feb-2019

Last entry update

10-Apr-2025

Version number