Cellosaurus cell line GM05823+hTERT (CVCL

Cellosaurus GM05823+hTERT (CVCL_VL10)

Cross-references
Cell line name	GM05823+hTERT
Synonyms	GM05823-hTert; hTERT+ GM05823
Accession	CVCL_VL10
Resource Identification Initiative	To cite this cell line use: GM05823+hTERT (RRID:CVCL_VL10)
Comments	Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:795; ATM; Simple; p.Leu2427_Arg2428del (c.7278_7283delCCTTAG); ClinVar=VCV000003020; Zygosity=Heterozygous (from parent cell line).
Disease	Ataxia telangiectasia syndrome (NCIt: C2887) Ataxia telangiectasia (ORDO: Orphanet_100)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_7441 (AT5BI)
Sex of cell	Male
Age at sampling	18Y
Category	Telomerase immortalized cell line
Publications	PubMed=11313956; DOI=10.1038/sj.onc.1204072 Lauren D. Wood, Tanya Lynn Halvorsen, Sonu Dhar, Joseph A. Baur, Raj Kumari Pandita, Woodring Erik Wright, M. Prakash Hande, Gloria Calaf, Tom K. Hei, Fred Levine, Jerry W. Shay ...Show all 13 authors... , Jean J.Y. Wang, Tej K. Pandita; Show fewer authors Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression. Oncogene 20:278-288(2001) PubMed=21149446; DOI=10.1074/jbc.M110.204065; PMCID=PMC3059052 Sergei V. Kozlov, Mark E. Graham, Burkhard Jakob, Frank Tobias, Amanda W. Kijas, Marcel Tanuji, Philip Chen, Phillip James Robinson, Gisela Taucher-Scholz, Keiji Suzuki, Sairai So ...Show all 13 authors... , David Chen, Martin Francis Lavin; Show fewer authors Autophosphorylation and ATM activation: additional sites add to the complexity. J. Biol. Chem. 286:9107-9119(2011)
Encyclopedic resources	Wikidata; Q93789883
Entry history
Entry creation	07-Sep-2018
Last entry update	19-Dec-2024
Version number	11