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Cellosaurus GM02052A-hTERT (CVCL_VL04)

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Cell line name GM02052A-hTERT
Synonyms GM02052A-hTert
Accession CVCL_VL04
Resource Identification Initiative To cite this cell line use: GM02052A-hTERT (RRID:CVCL_VL04)
Comments Population: Jewish; Moroccan.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Arg35Ter (c.103C>T); ClinVar=VCV000003025; Zygosity=Homozygous (from parent cell line).
Disease Ataxia telangiectasia syndrome (NCIt: C2887)
Ataxia telangiectasia (ORDO: Orphanet_100)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7350 (GM02052)
Sex of cell Female
Age at sampling 15Y
Category Telomerase immortalized cell line
Publications

PubMed=12446774; DOI=10.1128/mcb.22.24.8552-8561.2002; PMCID=PMC139882
Timothy P. Heffernan, Dennis A. Simpson, Alexandra R. Frank, Alexandra N. Heinloth, Richard S. Paules, Marila Cordeiro-Stone, William K. Kaufmann;
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.
Mol. Cell. Biol. 22:8552-8561(2002)

PubMed=21149446; DOI=10.1074/jbc.M110.204065; PMCID=PMC3059052
Sergei V. Kozlov, Mark E. Graham, Burkhard Jakob, Frank Tobias, Amanda W. Kijas, Marcel Tanuji, Philip Chen, Phillip James Robinson, Gisela Taucher-Scholz, Keiji Suzuki, Sairai So ...Show all 13 authors... , David Chen, Martin Francis Lavin; Show fewer authors
Autophosphorylation and ATM activation: additional sites add to the complexity.
J. Biol. Chem. 286:9107-9119(2011)

Cross-references
Encyclopedic resources Wikidata; Q93575554
Entry history
Entry creation07-Sep-2018
Last entry update14-Aug-2025
Version number11