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Cellosaurus AT-LD2-hTERT (CVCL_VL03)

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Cell line name AT-LD2-hTERT
Accession CVCL_VL03
Resource Identification Initiative To cite this cell line use: AT-LD2-hTERT (RRID:CVCL_VL03)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:7230; MRE11; Simple; p.Arg633Ter (c.1897C>T); ClinVar=VCV000008782; Zygosity=Homozygous (from parent cell line).
Disease Ataxia-telangiectasia-like disorder 1 (NCIt: C132224)
Ataxia-telangiectasia-like disorder (ORDO: Orphanet_251347)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VL02 (AT-LD2)
Sex of cell Male
Age at sampling 20Y
Category Telomerase immortalized cell line
Publications

PubMed=12446774; DOI=10.1128/mcb.22.24.8552-8561.2002; PMCID=PMC139882
Timothy P. Heffernan, Dennis A. Simpson, Alexandra R. Frank, Alexandra N. Heinloth, Richard S. Paules, Marila Cordeiro-Stone, William K. Kaufmann;
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.
Mol. Cell. Biol. 22:8552-8561(2002)

Cross-references
Encyclopedic resources Wikidata; Q93326265
Entry history
Entry creation07-Sep-2018
Last entry update14-Aug-2025
Version number10