• Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=21156289).
  
• Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Arg24Leu (c.71G>T); ClinVar=VCV000376377; Zygosity=Unspecified (PubMed=21156289).
  
• Mutation; HGNC; HGNC:11355; STAG2; Simple; p.Lys1083Ter (c.3247A>T); Zygosity=Unspecified (PubMed=27500726).
  

PubMed=21156289; DOI=10.1016/j.ccr.2010.11.023; PMCID=PMC3026446
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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
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PubMed=27500726; DOI=10.1038/nm.4155; PMCID=PMC5014622
Che-Hung Shen, Sun Hye Kim, Sebastian Trousil, Dennie T. Frederick, Adriano Piris, Ping Yuan, Li Cai, Lei Gu, Man Li, Jung Hyun Lee, Devarati Mitra ...Show all 15 authors... , David Erich Fisher, Ryan Joseph Sullivan, Keith Thomas Flaherty, Bin Zheng; Show fewer authors
Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.
Nat. Med. 22:1056-1061(2016)