Cellosaurus cell line ORL-247 (CVCL

Cellosaurus ORL-247 (CVCL_VJ49)

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Cell line name

ORL-247

Synonyms

ORL-247T; 247T

Accession

CVCL_VJ49

Resource Identification Initiative

To cite this cell line use: ORL-247 (RRID:CVCL_VJ49)

Comments

Population: Indian.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.

Sequence variations

Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.151-1G>A; ClinVar=VCV000635365; Zygosity=Homozygous; Note=Splice acceptor mutation (PubMed=27050151).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.His214Glnfs*7 (c.642_643delTA); ClinVar=VCV000826394; Zygosity=Unspecified (PubMed=27050151).

Disease

Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

38Y

Category

Cancer cell line

STR profile

Source(s): PubMed=27050151

Markers:

Amelogenin	X
CSF1PO	10,12
D5S818	12
D7S820	11
D13S317	11,12
D16S539	10,12
D21S11	29,32.2
TH01	6,9.3
TPOX	8
vWA	16,17

Publications

PubMed=24224046; DOI=10.1371/journal.pone.0080229; PMCID=PMC3817115
Sharifah Nurain Syed Zanaruddin, Pei-San Yee, Seen Yii Hor, Yink Heay Kong, Wan Maria Nabillah Wan Abd Ghani, Wan Mahadzir Wan Mustafa, Rosnah Binti Zain, Stephen S. Prime, Zainal Ariff Abdul Rahman, Sok-Ching Cheong;
Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin.
PLoS ONE 8:e80229.1-e80229.12(2013)

PubMed=27050151; DOI=10.18632/oncotarget.8533; PMCID=PMC5053689
Muhammad Zaki Hidayatullah Fadlullah, Ivy Kim-Ni Chiang, Kalen R. Dionne, Pei-San Yee, Chai Phei Gan, Kin Kit Sam, Kai Hung Tiong, Adrian Kwok Wen Ng, Daniel Martin, Kue Peng Lim, Thomas George Kallarakkal ...Show all 21 authors... , Wan Mahadzir Wan Mustafa, Shin Hin Lau, Mannil Thomas Abraham, Rosnah Binti Zain, Zainal Ariff Abdul Rahman, Alfredo Alberto Molinolo, Vyomesh Patel, Jorge Silvio Gutkind, Aik-Choon Tan, Sok-Ching Cheong; Show fewer authors
Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies.
Oncotarget 7:27802-27818(2016)

Cross-references

Encyclopedic resources

Wikidata; Q98128369

Polymorphism and mutation databases

Cosmic; 2531654
Cosmic; 2559749

Entry history

Entry creation

07-Sep-2018

Last entry update

10-Apr-2025

Version number