Cellosaurus logo
expasy logo

Cellosaurus U266/BR (CVCL_VJ36)

[Text version]
Cell line name U266/BR
Accession CVCL_VJ36
Resource Identification Initiative To cite this cell line use: U266/BR (RRID:CVCL_VJ36)
Comments Population: Caucasian.
Characteristics: Produces IgE lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI_52717; Bortezomib (Velcade).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0566 (U266B1)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=25382610; DOI=10.1038/bcj.2014.74; PMCID=PMC5424099
Kasyapa S. Chitta, Aneel Paulus, Thomas R. Caulfield, Sharoon Akhtar, Maja Kristin Kuranz Blake, Sikander Ailawadhi, Joshua Knight, Michael G. Heckman, Anthony B. Pinkerton, Asher A. Chanan-Khan;
Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenstroms macroglobulinemia.
Blood Cancer J. 4:e260.1-e260.10(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VJ36
Encyclopedic resources Wikidata; Q98133719
Entry history
Entry creation07-Sep-2018
Last entry update14-Aug-2025
Version number12