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Cellosaurus HiDEP-2 (CVCL_VI04)

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Cell line name HiDEP-2
Synonyms Human iPS cell-Derived Erythroid Progenitor-2
Accession CVCL_VI04
Resource Identification Initiative To cite this cell line use: HiDEP-2 (RRID:CVCL_VI04)
Comments Population: Japanese.
Characteristics: After in vitro induction of differentiation, will produce enucleated red blood cells.
Characteristics: Expression of the HPV16 E6 and E7 genes is induced by tetracycline (PubMed=23533656).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11556; TAL1.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Cell type: Erythroid progenitor cell; CL=CL_0000038.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VI01 (HiPS-RIKEN-3A-TAL1)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=23533656; DOI=10.1371/journal.pone.0059890; PMCID=PMC3606290
Ryo Kurita, Noriko Suda, Kazuhiro Sudo, Kenichi Miharada, Takashi Hiroyama, Hiroyuki Miyoshi, Kenzaburo Tani, Yukio Nakamura;
Establishment of immortalized human erythroid progenitor cell lines able to produce enucleated red blood cells.
PLoS ONE 8:e59890.1-e59890.15(2013)

Patent=US8975072
Yukio Nakamura, Ryo Kurita;
Human erythroid progenitor cell line comprising HPV E6/E7 operably linked to an inducible promoter and method for producing human enucleated red blood cells.
Patent number US8975072, 10-Mar-2015

Cross-references
Cell line collections (Providers) RCB; RCB4555
Encyclopedic resources Wikidata; Q54889537
Entry history
Entry creation14-May-2018
Last entry update14-Aug-2025
Version number13