Cellosaurus cell line HME348 hTERT (CVCL

Cellosaurus HME348 hTERT (CVCL_VG07)

Cross-references
Cell line name	HME348 hTERT
Synonyms	HME348hTERT
Accession	CVCL_VG07
Resource Identification Initiative	To cite this cell line use: HME348 hTERT (RRID:CVCL_VG07)
Comments	Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367. Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Sequence variations	Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Tyr2215Serfs*13 (c.6644_6647delACTC) (6872del4); ClinVar=VCV000038060; Zygosity=Heterozygous (PubMed=16541310).
Disease	BRCA2 syndrome (NCIt: C36101) Hereditary breast and ovarian cancer syndrome (ORDO: Orphanet_145)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_VG05 (HME348)
Sex of cell	Female
Age at sampling	44Y
Category	Telomerase immortalized cell line
Publications	PubMed=16541310; DOI=10.1007/s10549-006-9189-9 Cheryl M. Lewis, Brittney-Shea Herbert, Da-Wei Bu, Shane Halloway, Adam Beck, Ashleen Shadeo, Cindy Zhang, Raheela Ashfaq, Jerry W. Shay, David Michael Euhus; Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier. Breast Cancer Res. Treat. 99:103-115(2006) PubMed=22019625; DOI=10.1016/j.mrfmmm.2011.10.002 Sigridur Klara Bodvarsdottir, Margret Steinarsdottir, Hordur Bjarnason, Jorunn Erla Eyfjord; Dysfunctional telomeres in human BRCA2 mutated breast tumors and cell lines. Mutat. Res. 729:90-99(2012)
Encyclopedic resources	Wikidata; Q54889920
Entry history
Entry creation	14-May-2018
Last entry update	14-Aug-2025
Version number	13