Cellosaurus cell line Penl1 (CVCL

Cellosaurus Penl1 (CVCL_VF93)

[Text version]

Cell line name

Penl1

Accession

CVCL_VF93

Resource Identification Initiative

To cite this cell line use: Penl1 (RRID:CVCL_VF93)

Comments

Population: Chinese.
Characteristics: Sensitive to both cisplatin and epirubicin however is resistant to anti-EGFR therapy and unresponsive to androgen (ABM=T8328).
Doubling time: ~27 hours (PubMed=27351128); 28.16 hours (PubMed=29880898).
Omics: Genomics; Whole genome sequencing.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.

Sequence variations

Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Unspecified (PubMed=29880898).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro72Arg (c.215C>G); ClinVar=VCV000012351; Zygosity=Unspecified (PubMed=27351128; PubMed=29880898).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg283Pro (c.848G>C); ClinVar=VCV000486555; Zygosity=Unspecified (PubMed=27351128; PubMed=29880898).

Disease

Squamous cell carcinoma of the penis (NCIt: C7729)
Squamous cell carcinoma of the penis (ORDO: Orphanet_398058)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

41Y

Category

Cancer cell line

STR profile

Source(s): PubMed=27351128; PubMed=29880898

Markers:

Amelogenin	X,Y
CSF1PO	12
D5S818	13
D7S820	11
D13S317	9,12
D16S539	11,12
TH01	7,9
TPOX	8,11
vWA	18

Publications

PubMed=27351128; DOI=10.18632/oncotarget.10098; PMCID=PMC5239507
Jie-Ping Chen, Kai Yao, Zai-Shang Li, Chuang-Zhong Deng, Liang-Jiao Wang, Xing-Su Yu, Pei-Li Liang, Qian-Kun Xie, Peng Chen, Zi-Ke Qin, Yun-Lin Ye ...Show all 15 authors... , Zhuo-Wei Liu, Fang-Jian Zhou, Zhen-Feng Zhang, Hui Han; Show fewer authors
Establishment and characterization of a penile cancer cell line, penl1, with a deleterious TP53 mutation as a paradigm of HPV-negative penile carcinogenesis.
Oncotarget 7:51687-51698(2016)

PubMed=28344882; DOI=10.1080/2162402X.2016.1269047; PMCID=PMC5353932
Chuang-Zhong Deng, Zai-Shang Li, Sheng-Jie Guo, Peng Chen, Xiao-Feng Chen, Qiang-Hua Zhou, Jie-Ping Chen, Xing-Su Yu, Xiao-Liang Wu, Wen-Juan Ma, Qian-Kun Xie ...Show all 20 authors... , Yun-Lin Ye, Yong-Hong Li, Zi-Ke Qin, Zhuo-Wei Liu, Ran-Yi Liu, Zhen-Feng Zhang, Kai Yao, Hui Han, Fang-Jian Zhou; Show fewer authors
Tumor PD-L1 expression is correlated with increased TILs and poor prognosis in penile squamous cell carcinoma.
OncoImmunology 6:e1269047.1-e1269047.8(2017)

PubMed=29880898; DOI=10.1038/s41419-018-0736-1; PMCID=PMC5992159
Qiang-Hua Zhou, Chuang-Zhong Deng, Zai-Shang Li, Jie-Ping Chen, Kai Yao, Kang-Bo Huang, Tian-Yu Liu, Zhuo-Wei Liu, Zi-Ke Qin, Fang-Jian Zhou, Wei Huang ...Show all 13 authors... , Hui Han, Ran-Yi Liu; Show fewer authors
Molecular characterization and integrative genomic analysis of a panel of newly established penile cancer cell lines.
Cell Death Dis. 9:684.1-684.14(2018)

Cross-references

Cell line collections (Providers)

ABM; T8328

Cell line databases/resources

cancercelllines; CVCL_VF93

Encyclopedic resources

Wikidata; Q54946918

Polymorphism and mutation databases

Cosmic; 2806800
Cosmic; 2806954

Entry history

Entry creation

14-May-2018

Last entry update

10-Apr-2025

Version number