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Cellosaurus CHL-2 (CVCL_V643)

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Cell line name CHL-2
Accession CVCL_V643
Resource Identification Initiative To cite this cell line use: CHL-2 (RRID:CVCL_V643)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9451.
Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:9051; PLAT.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:2352; CREM + HGNC; HGNC:3508; EWSR1; Name(s)=EWSR1-CREM (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Trp110Ter (c.330G>A) (p.Gly125Arg, c.373G>A); ClinVar=VCV000376303; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6877; MAPK3; Simple; p.Ile228Val (c.682A>G); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His193Arg (c.578A>G); ClinVar=VCV000184979; Zygosity=Homozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1122 (CHL-1)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-9451

Markers:
AmelogeninX
CSF1PO10
D5S81811,12
D7S82011,13
D13S3178,11
D16S53913
TH019,9.3
TPOX8
vWA17

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Publications

Patent=US5017478
Linda M. Cashion, Kathi Begley, Wendy Colby, Michael J. Morser;
Transfected cells containing plasmids having genes oriented in opposing directions and methods of using.
Patent number US5017478, 21-May-1991

Cross-references
Cell line collections (Providers) ATCC; CRL-9451 - Discontinued
Cell line databases/resources cancercelllines; CVCL_V643
Encyclopedic resources Wikidata; Q54812130
Entry history
Entry creation16-Apr-2014
Last entry update14-Aug-2025
Version number22