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Cellosaurus HCC827 GR8 (CVCL_V625)

[Text version]
Cell line name HCC827 GR8
Accession CVCL_V625
Resource Identification Initiative To cite this cell line use: HCC827 GR8 (RRID:CVCL_V625)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=17463250; DOI=10.1126/science.1141478
Jeffrey Adam Engelman, Kreshnik Zejnullahu, Tetsuya Mitsudomi, Youngchul Song, Courtney Hyland, Joon Oh Park, Neal I. Lindeman, Christopher-Michael Gale, Xiao-Jun Zhao, James Gail Christensen, Takayuki Kosaka ...Show all 19 authors... , Alison J. Holmes, Andrew M. Rogers, Federico Cappuzzo, Tony Mok, Charles Lee, Bruce E. Johnson, Lewis Clayton Cantley, Pasi Antero Janne; Show fewer authors
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
Science 316:1039-1043(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_V625
Encyclopedic resources Wikidata; Q54881794
Gene expression databases GEO; GSM466325
Polymorphism and mutation databases Progenetix; CVCL_V625
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number16