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Cellosaurus HCC827 GR6 (CVCL_V623)

[Text version]
Cell line name HCC827 GR6
Accession CVCL_V623
Resource Identification Initiative To cite this cell line use: HCC827 GR6 (RRID:CVCL_V623)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC426

Markers:
AmelogeninX
CSF1PO11
D3S135817
D5S81812
D7S82011,12
D8S117912
D13S3179
D16S53912
D18S5113
D21S1131
FGA24
Penta D14
Penta E19,20
TH016
TPOX8
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=17463250; DOI=10.1126/science.1141478
Jeffrey Adam Engelman, Kreshnik Zejnullahu, Tetsuya Mitsudomi, Youngchul Song, Courtney Hyland, Joon Oh Park, Neal I. Lindeman, Christopher-Michael Gale, Xiao-Jun Zhao, James Gail Christensen, Takayuki Kosaka ...Show all 19 authors... , Alison J. Holmes, Andrew M. Rogers, Federico Cappuzzo, Tony Mok, Charles Lee, Bruce E. Johnson, Lewis Clayton Cantley, Pasi Antero Janne; Show fewer authors
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
Science 316:1039-1043(2007)

Cross-references
Cell line collections (Providers) Millipore; SCC426
Cell line databases/resources cancercelllines; CVCL_V623
Encyclopedic resources Wikidata; Q54881791
Gene expression databases GEO; GSM466323
Polymorphism and mutation databases Progenetix; CVCL_V623
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number19