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Cellosaurus F5 (CVCL_V616)

[Text version]
Cell line name F5
Accession CVCL_V616
Resource Identification Initiative To cite this cell line use: F5 (RRID:CVCL_V616)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 46 hours (PubMed=25984343); 1 day (PubMed=34850056).
Omics: Genomics; Whole exome sequencing.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (DepMap=ACH-001067).
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.76
Native American0
East Asian, North3.58
East Asian, South0
South Asian0
European, North60.4
European, South33.25
Disease Meningioma (NCIt: C3230)
Meningioma (ORDO: Orphanet_2495)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=7542695; DOI=10.1007/BF01058456
Takahito Yazaki, Yoshiaki Takamiya, Penelope C. Costello, Toshihiro Mineta, Anil G. Menon, Samuel David Rabkin, Robert Lawrence Martuza;
Inhibition of angiogenesis and growth of human non-malignant and malignant meningiomas by TNP-470.
J. Neurooncol. 23:23-29(1995)

PubMed=7585498
Takahito Yazaki, Herbert J. Manz, Samuel David Rabkin, Robert Lawrence Martuza;
Treatment of human malignant meningiomas by G207, a replication-competent multimutated herpes simplex virus 1.
Cancer Res. 55:4752-4756(1995)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=34850056; DOI=10.1093/jnen/nlab111; PMCID=PMC8716066
Erik Janos Uhlmann, Rosalia Rabinovsky, Hemant Varma, Rachid El Fatimy, Ekkehard M. Kasper, Justin M. Moore, Rafael A. Vega, Ajith J. Thomas, Ronald L. Alterman, Martina Stippler, Matthew P. Anderson ...Show all 14 authors... , Erik N. Uhlmann, Franciele Cristina Kipper, Anna M. Krichevsky; Show fewer authors
Tumor-derived cell culture model for the investigation of meningioma biology.
J. Neuropathol. Exp. Neurol. 80:1117-1124(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_V616
Cell_Model_Passport; SIDM01497
DepMap; ACH-001067
Anatomy/cell type resources BTO; BTO_0004530
CRISP screens repositories BioGRID_ORCS_Cell_line; 434
Chemistry resources PharmacoDB; F5_364_2019
Encyclopedic resources Wikidata; Q54833148
Polymorphism and mutation databases Progenetix; CVCL_V616
Entry history
Entry creation16-Apr-2014
Last entry update10-Apr-2025
Version number19