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Cellosaurus SLR21 (CVCL_V607)

[Text version]
Cell line name SLR21
Synonyms SLR 21
Accession CVCL_V607
Resource Identification Initiative To cite this cell line use: SLR21 (RRID:CVCL_V607)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 60 hours (PubMed=25984343).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; shRNA library screening.
Miscellaneous: STR profile from personal communication of von Teichman, Adriana.
Derived from site: Metastatic; Not specified.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.09
Native American0.64
East Asian, North0
East Asian, South0.43
South Asian1.26
European, North66.35
European, South31.24
Disease Clear cell renal cell carcinoma (NCIt: C4033)
Clear cell renal carcinoma (ORDO: Orphanet_319276)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO11,13
D3S135814,16
D5S81812,13
D7S82010,11
D8S11798,15
D13S31712,14
D16S53910,12
D18S5113,16
D21S1128,29
FGA23
Penta D9,10
Penta E7,14
TH019.3
TPOX8
vWA17,20

Run an STR similarity search on this cell line
Publications

PubMed=12907621
Tomohide Tatsumi, Christopher J. Herrem, William C. Olson, James H. Finke, Ronald M. Bukowski, Michael Scott Kinch, Elena Ranieri, Walter J. Storkus;
Disease stage variation in CD4+ and CD8+ T-cell reactivity to the receptor tyrosine kinase EphA2 in patients with renal cell carcinoma.
Cancer Res. 63:4481-4489(2003)

PubMed=19470766; DOI=10.1158/0008-5472.CAN-09-0146; PMCID=PMC2745239
Rameen Beroukhim, Jean-Philippe Brunet, Arianna Di Napoli, Kirsten D. Mertz, Apryle Seeley, Maira M. Pires, David Linhart, Robert A. Worrell, Holger Moch, Mark A. Rubin, William Raj Sellers ...Show all 15 authors... , Matthew Langer Meyerson, William Marston Linehan, William G. Kaelin Jr., Sabina Signoretti; Show fewer authors
Patterns of gene expression and copy-number alterations in von-Hippel Lindau disease-associated and sporadic clear cell carcinoma of the kidney.
Cancer Res. 69:4674-4681(2009)

PubMed=22949125; DOI=10.1002/ijc.27822
Rafal Pawlowski, Sarah M. Muhl, Tullio Sulser, Wilhelm Krek, Holger Moch, Peter Schraml;
Loss of PBRM1 expression is associated with renal cell carcinoma progression.
Int. J. Cancer 132:E11-E17(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=28489074; DOI=10.1038/ncomms15165; PMCID=PMC5436135
Rileen Sinha, Andrew G. Winer, Michael Stephen Chevinsky, Christopher Jakubowski, Ying-Bei Chen, Yi-Yu Dong, Satish K. Tickoo, Victor E. Reuter, Paul Russo, Jonathan A. Coleman, Chris Sander ...Show all 13 authors... , James J.-D. Hsieh, Abraham Ari Hakimi; Show fewer authors
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165.1-15165.10(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_V607
Cell_Model_Passport; SIDM01862
DepMap; ACH-000016
Biological sample resources BioSample; SAMN10988415
Chemistry resources PharmacoDB; SLR21_1422_2019
Encyclopedic resources Wikidata; Q54954872
Gene expression databases GEO; GSM374468
Polymorphism and mutation databases Cosmic; 2520630
Progenetix; CVCL_V607
Entry history
Entry creation16-Apr-2014
Last entry update10-Apr-2025
Version number18