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Cellosaurus Karpas-299-CR06 (CVCL_V404)

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Cell line name Karpas-299-CR06
Synonyms KARPAS-299-CR06; K299CR06
Accession CVCL_V404
Resource Identification Initiative To cite this cell line use: Karpas-299-CR06 (RRID:CVCL_V404)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_64310; Crizotinib (Xalkori).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:7910; NPM1; Name(s)=NPM1-ALK (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Homozygous (from parent cell line).
Disease Anaplastic large cell lymphoma, ALK-positive (NCIt: C37193)
ALK-positive anaplastic large cell lymphoma (ORDO: Orphanet_300895)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1324 (Karpas-299)
Sex of cell Male
Age at sampling 25Y
Category Cancer cell line
Publications

PubMed=23239810; DOI=10.1158/1541-7786.MCR-12-0569
Monica Ceccon, Luca Mologni, William H. Bisson, Leonardo Scapozza, Carlo Gambacorti-Passerini;
Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors.
Mol. Cancer Res. 11:122-132(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_V404
Encyclopedic resources Wikidata; Q54899496
Polymorphism and mutation databases Cosmic; 1849569
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number18