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Cellosaurus MDA-MB-231-MEK-R (CVCL_V403)

[Text version]
Cell line name MDA-MB-231-MEK-R
Accession CVCL_V403
Resource Identification Initiative To cite this cell line use: MDA-MB-231-MEK-R (RRID:CVCL_V403)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:88249; 391210-10-9 (PD0325901).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=22402123; DOI=10.1158/1535-7163.MCT-11-1010
Hatzivassiliou G., Liu B., O'Brien C., Spoerke J.M., Hoeflich K.P., Haverty P.M., Soriano R., Forrest W.F., Heldens S., Chen H.-F., Toy K., Ha C., Zhou W., Song K., Friedman L.S., Amler L.C., Hampton G.M., Moffat J., Belvin M.P., Lackner M.R.
ERK inhibition overcomes acquired resistance to MEK inhibitors.
Mol. Cancer Ther. 11:1143-1154(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_V403
Encyclopedic resources Wikidata; Q54904605
Polymorphism and mutation databases Cosmic; 1927243
Entry history
Entry creation16-Apr-2014
Last entry update05-Oct-2023
Version number20