| Cell line name |
LoVo-MEK-R |
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| Accession |
CVCL_V402 |
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| Resource Identification Initiative |
To cite this cell line use: LoVo-MEK-R (RRID:CVCL_V402) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_88249; 391210-10-9 (PD0325901).
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
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| Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Arg1114Ter (c.3340C>T); ClinVar=VCV000236589; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Met1431fs*42 (c.4289delC) (p.T1430fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Arg2816Gln (c.8447G>A); ClinVar=VCV000419681; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:914; B2M; Simple; p.Leu15Phefs*41 (c.43_44delCT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6768; SMAD2; Simple; p.Ala292Val (c.875C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0399 (LoVo) |
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| Sex of cell |
Male |
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| Age at sampling |
56Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=22402123; DOI=10.1158/1535-7163.MCT-11-1010
Georgia Hatzivassiliou, Bonnie Liu, Carol O'Brien, Jill M. Spoerke, Klaus P. Hoeflich, Peter M. Haverty, Robert H. Soriano, William F. Forrest, Sherry L. Heldens, Hui-Fen Chen, Karen Toy ...Show all 20 authors... , Connie Ha, Wei Zhou, Kyung Song, Lori S. Friedman, Lukas C. Amler, Garret M. Hampton, John Moffat, Marcia P. Belvin, Mark R. Lackner; Show fewer authors
ERK inhibition overcomes acquired resistance to MEK inhibitors.
Mol. Cancer Ther. 11:1143-1154(2012) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_V402
|
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| Encyclopedic resources |
Wikidata; Q54902903
|
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| Polymorphism and mutation databases |
Cosmic; 1927245
|
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| Entry history |
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| Entry creation | 16-Apr-2014 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 18 |
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