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Cellosaurus MCF7 Tet-Off (CVCL_V357)

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Cell line name MCF7 Tet-Off
Synonyms MCF-7 Tet-Off
Accession CVCL_V357
Resource Identification Initiative To cite this cell line use: MCF7 Tet-Off (RRID:CVCL_V357)
Comments Population: Caucasian.
Characteristics: Transfected with the tetracycline transactivator (tTA) protein, a fusion of tetR with the activation domain of HSV-1 VP16.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 (HHV-1) VP16 (UL28) (Note=With p.Met1_Arg360del).
Discontinued: Takara/Clontech; Catalog number 630907.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Cross-references
Cell line databases/resources cancercelllines; CVCL_V357
Encyclopedic resources Wikidata; Q54904451
Proteomic databases PRIDE; PXD001202
Entry history
Entry creation16-Apr-2014
Last entry update14-Aug-2025
Version number20