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Cellosaurus (CVCL_V067)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
From: International Agency of Research on Cancer (IARC); Lyon; France.
Population: Caucasian.
Virology: EBV-negative.
Doubling time: ~30 hours (DSMZ=ACC-160).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq virome analysis.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
HLA typing Source: PubMed=25960936
Class I
HLA-AA*11:01,32:01
HLA-BB*35:01,49:01
HLA-CC*04:01,07:01
Class II
HLA-DQDQA1*01:01,01:01
DQB1*05:03,05:03
HLA-DRDRB1*01:01,14:01

Source: PubMed=26589293
Class I
HLA-AA*32:01,32:01
HLA-BB*35:01,49:01
HLA-CC*04:01,07:06
Class II
HLA-DQDQA1*01:01,01:01
DQB1*05:03,05:03
HLA-DRDRB1*01:01,14:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.05
Native American0.06
East Asian, North0
East Asian, South0.52
South Asian1.34
European, North57.31
European, South40.71
Disease Burkitt lymphoma (NCIt: C2912)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_IV22 ! IARC-171
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=910706; DSMZ=ACC-160

Markers:

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications





Barbara A. Spengler, June Lee Biedler;
Coordinate morphological and biochemical interconversion of human neuroblastoma cells.
J. Natl. Cancer Inst. 71:741-747(1983)



growth factor production by neoplastic epithelial cells.
J. Natl. Cancer Inst. 75:471-482(1985)


Alain E. Lagarde;
Autonomous proliferation of MeWo human melanoma cell lines in serum-free medium: secretion of growth-stimulating activities.
Int. J. Cancer 37:123-132(1986)


James E. Schwob;
Monoclonal antibodies to glutamic acid decarboxylase.
Proc. Natl. Acad. Sci. U.S.A. 83:8808-8812(1986)



yolk-sac carcinoma.
Int. J. Cancer 40:334-343(1987)



Identification of a monoclonal antibody specific for a murine T3 polypeptide.
Proc. Natl. Acad. Sci. U.S.A. 84:1374-1378(1987)




EMBO J. 7:1635-1645(1988)


Masaki Yasukawa, Kohsuke Yanagisawa, Hidehisa Kohno, Yoshihiro Yakushijin, Toshifumi Kondo, Shigeru Fujita;
Simultaneous establishment of myeloid and B-lymphoid cell lines with identical chromosome abnormalities from Philadelphia chromosome-positive chronic myelogenous leukaemia.
Br. J. Haematol. 82:515-521(1992)


Yoshiaki Ohsugi, Masao Nakagawa;
Establishment of a novel myeloma cell line KPMM2 carrying t(3;14)(q21;q32), which proliferates specifically in response to interleukin-6 through an autocrine mechanism.
Leukemia 9:711-718(1995)




Cancer Res. 56:5146-5149(1996)


Yasusada Miura;
In vitro development of erythroid and megakaryocytic cells from a UT-7 subline, UT-7/GM.
Blood 89:4021-4033(1997)



clinical prostate cancers and breast tissues, immunohistochemically demonstrated by a newly established neutralizing monoclonal antibody against FGF 8.
Cancer Res. 58:2053-2056(1998)




Genes Chromosomes Cancer 26:376-380(1999)



frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
Blood 103:1085-1088(2004)


Anthony Po-Wing Yuen, George Sai-Wah Tsao;
Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase.
Int. J. Cancer 119:1567-1576(2006)


Paula D. Bos, Xiang H.-F. Zhang, Cristina Nadal, Wei-Ping Shu, Roger R. Gomis, Don X. Nguyen, Andy J. Minn, Marc Joan van de Vijver, William Levi Gerald, John A. Foekens, Joan Massague;
Genes that mediate breast cancer metastasis to the brain.
Nature 459:1005-1009(2009)



switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)


Julie Adam, Ann Hedley, Gabriela Kalna, Ian Philip Mark Tomlinson, Patrick John Pollard, David George Watson, Ralph J. DeBerardinis, Tomer Shlomi, Eytan Ruppin, Eyal Gottlieb;
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature 477:225-228(2011)


Zi-Bin Bu, Rui-Fang Liu, Bing-Xue Shang, Zhi-Fei Cao, Yan-Yan Pan, Quan-Sheng Zhou, Chang-Geng Ruan;
A monoclonal antibody SZ-117 that recognizes filamin A derived from tumor cells.
Hybridoma 31:214-218(2012)


Hai-Peng Zhang, Hai-Yan Lv, Xiao-Li Chen, Jiang-Hua Yan, Fang-Hong Luo;
A monoclonal antibody against the catalytic domain of PTP1B.
Hybridoma 31:209-213(2012)


Turid Knutsen, Raluca Yonescu, Danny Wangsa, Kathleen Dorritie, Linda Barenboim-Stapleton, Yue Hu, Thomas Ried;
Spontaneous transformation of murine epithelial cells requires the early acquisition of specific chromosomal aneuploidies and genomic imbalances.
Genes Chromosomes Cancer 51:353-374(2012)



arenaviruses, the etiological agents of boid inclusion body disease.
J. Virol. 87:10918-10935(2013)


Hangnoh Lee, Charles Joel McManus, Dong-Yeon Cho, Matthew Eaton, Fioranna Renda, Maria Patrizia Somma, Lucy Cherbas, Gemma May, Sara Powell, Da-Yu Zhang, Li-Jun Zhan ...Show all 20 authors... , Alissa Resch, Justen Andrews, Susan E. Celniker, Peter Cherbas, Teresa Maria Przytycka, Maurizio Gatti, Brian Oliver, Brenton R. Graveley, David M. MacAlpine; Show fewer authors
DNA copy number evolution in Drosophila cell lines.
Genome Biol. 15:R70.1-R70.20(2014)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)




BMC Cancer 15:240.1-240.16(2015)



literature.
Cancer Res. 77:2784-2788(2017)


Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)


Richard G. Saul, Jan A. Kaczmarczyk, Suzanne D. Borgel, Sergio Y. Alcoser, Melinda G. Hollingshead, Young H. Lee, Donald P. Bottaro, Tara Hiltke, Gordon R. Whiteley, Naoko Takebe, Robert J. Kinders ...Show all 14 authors... , Ralph E. Parchment, Joseph E. Tomaszewski, James H. Doroshow; Show fewer authors
Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells.
PLoS ONE 13:e0199361.1-e0199361.24(2018)




Cancer Cell 33:386-400.e5(2018)


Clara Llorente-Gonzalez, Manuel Sanchez-Martin, Miguel Vicente-Manzanares, Eugenio Santos, Balbino Alarcon, Jose Manuel Garcia-Aznar, Mercedes Dosil, Xose R. Bustelo;
Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors.
Oncogene 42:389-405(2023)

Cross-references
Cell line collections (Providers) DSMZ; ACC-160
NCBI_Iran; C493
Cell line databases/resources Cell_Model_Passport; SIDM00985
Cosmic-CLP; 910706
DepMap; ACH-000245
DSMZCellDive; ACC-160
LINCS_LDP; LCL-2028
Chemistry resources ChEMBL-Cells; CHEMBL3308526
ChEMBL-Targets; CHEMBL2366173
GDSC; 910706
PharmacoDB; BL41_103_2019
PubChem_Cell_line; CVCL_1087
Encyclopedic resources Wikidata; Q54797155
Gene expression databases GEO; GSM119535
GEO; GSM862863
GEO; GSM862864
GEO; GSM862865
GEO; GSM862866
GEO; GSM886889
GEO; GSM887954
GEO; GSM1669625
GEO; GSM3150241
Polymorphism and mutation databases Cosmic; 910706
Cosmic; 931099
Cosmic; 991550
Cosmic; 1086324
Cosmic; 1818339
Cosmic; 2297031
Cosmic; 2361383
Cosmic; 2814533
IARC_TP53; 700
IARC_TP53; 21194
LiGeA; CCLE_122
Progenetix; CVCL_1087
Proteomic databases PRIDE; PXD012087
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number43