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Cellosaurus LiF-EP (CVCL_UZ58)

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Cell line name LiF-EP
Accession CVCL_UZ58
Resource Identification Initiative To cite this cell line use: LiF-EP (RRID:CVCL_UZ58)
Comments Senescence: Senesces at ~35 PDL (PubMed=10648628).
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.993+1delG (IVS9+1delG); ClinVar=VCV000428898; Zygosity=Heterozygous; Note=Splice donor mutation (PubMed=10980596).
Disease Li-Fraumeni syndrome (NCIt: C3476)
Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UZ59 (LiF-EP/TERT-1)
Sex of cell Female
Age at sampling 60Y
Category Finite cell line
Web pages Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304
Mark A. Dickson, William Chun Hahn, Yasushi Ino, Vincent Ronfard, Jenny Y. Wu, Robert Allan Weinberg, David Neil Louis, Frederick Pei Li, James George Rheinwald;
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mol. Cell. Biol. 20:1436-1447(2000)

PubMed=10980596; DOI=10.1038/sj.onc.1203758
Sigitas Jonas Verselis, James George Rheinwald, Joseph Francis Fraumeni Jr., Frederick Pei Li;
Novel p53 splice site mutations in three families with Li-Fraumeni syndrome.
Oncogene 19:4230-4235(2000)

Cross-references
Encyclopedic resources Wikidata; Q95982190
Entry history
Entry creation25-Feb-2019
Last entry update10-Apr-2025
Version number10