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Cellosaurus RCC4/empty vector (CVCL_UY81)

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Cell line name RCC4/empty vector
Synonyms RCC4 plus vector alone
Accession CVCL_UY81
Resource Identification Initiative To cite this cell line use: RCC4/empty vector (RRID:CVCL_UY81)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; HGNC:12687; VHL; Simple; p.Ser65Trp (c.194C>G); ClinVar=VCV000043597; Zygosity=Hemizygous (from parent cell line).
Disease Clear cell renal cell carcinoma (NCIt: C4033)
Clear cell renal carcinoma (ORDO: Orphanet_319276)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0498 (RCC4)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC=03112702

Markers:
AmelogeninX
CSF1PO10,12
D5S81812
D7S8208.2
D13S31712
D16S53911
TH019.3
TPOX11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=10353251; DOI=10.1038/20459
Patrick Henry Maxwell, Michael S. Wiesener, Gin-Wen Chang, Steven C. Clifford, Emma C. Vaux, Matthew E. Cockman, Charles C. Wykoff, Christopher W. Pugh, Eamonn R. Maher, Peter John Ratcliffe;
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
Nature 399:271-275(1999)

Cross-references
Cell line collections (Providers) ECACC; 03112702
Cell line databases/resources cancercelllines; CVCL_UY81
Cell_Model_Passport; SIDM01921
Encyclopedic resources Wikidata; Q98128863
Entry history
Entry creation25-Feb-2019
Last entry update14-Aug-2025
Version number12