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Cellosaurus Ocy454 (CVCL_UW31)

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Cell line name Ocy454
Synonyms OCY454
Accession CVCL_UW31
Resource Identification Initiative To cite this cell line use: Ocy454 (RRID:CVCL_UW31)
Comments Characteristics: Displays a dendritic morphology similar to other osteocytic cell lines.
Characteristics: Expresses GFP Topaz under the control of the Dmp1 promoter.
Genetic integration: Method=Transgenic mouse; Gene=FPbase; SY6TH; Topaz (Note=Green/yellow fluorescent protein derived from GFP).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Derived from site: In situ; Bone, long bone; UBERON=UBERON_0002495.
Cell type: Osteocyte; CL=CL_0000137.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6-Tg(Dmp1-Topaz)1Ikal/J x (CBA/Ca x C57BL/10)Tg(H2Kb-tsA58) Immortomouse.
Sex of cell Sex unspecified
Age at sampling 4W
Category Conditionally immortalized cell line
Web pages Info; -; -; https://www.csr-mgh.org/wp-content/uploads/2017/04/OCY454-1.pdf
Publications

PubMed=25953900; DOI=10.1074/jbc.M114.628313; PMCID=PMC4505423
Jordan M. Spatz, Marc Nathan Wein, Jonathan H. Gooi, Yi-Li Qu, Jenna L. Garr, Shawn Liu, Kevin J. Barry, Yu-Hei Uda, Forest Lai, Christopher Dedic, Mercedes Balcells-Camps ...Show all 14 authors... , Henry Morris Kronenberg, Philip Babij, Paola Divieti Pajevic; Show fewer authors
The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro.
J. Biol. Chem. 290:16744-16758(2015)

PubMed=30977540; DOI=10.1002/jor.24302
Liang-Cheng Henry Xu, Han Shao, Yu-Heng Vivian Ma, Li-Dan You;
OCY454 osteocytes as an in vitro cell model for bone remodeling under mechanical loading.
J. Orthop. Res. 37:1681-1689(2019)

Cross-references
Encyclopedic resources Wikidata; Q98128331
Entry history
Entry creation25-Feb-2019
Last entry update14-Aug-2025
Version number11