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Cellosaurus MCL-1 (CVCL_UU63)

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Cell line name MCL-1
Accession CVCL_UU63
Resource Identification Initiative To cite this cell line use: MCL-1 (RRID:CVCL_UU63)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9562.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:2610; CYP2A6.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3401; EPHX1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_UU62 (AHH-1 TK+/- L3)
Sex of cell Male
Age at sampling 33Y
Category Transformed cell line
Publications

PubMed=2706743; DOI=10.1093/carcin/10.5.885
Robin L. Davies, Charles L. Crespi, Kenneth Rudo, Thomas R. Turner, Robert Langenbach;
Development of a human cell line by selection and drug-metabolizing gene transfection with increased capacity to activate promutagens.
Carcinogenesis 10:885-891(1989)

PubMed=8236284; DOI=10.1016/0300-483X(93)90062-W
Charles L. Crespi, Robert Langenbach, Bruce W. Penman;
Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450.
Toxicology 82:89-104(1993)

Patent=US5429948
Charles L. Crespi, Bruce W. Penman, Robin L. Davies;
Human cell line stably expressing 5 cDNAS encoding procarcinogen- activating enzymes and related mutagenicity assays.
Patent number US5429948, 04-Jul-1995

Cross-references
Encyclopedic resources Wikidata; Q95986959
Entry history
Entry creation25-Feb-2019
Last entry update10-Apr-2025
Version number11