Cellosaurus cell line MM253c1-3D (CVCL

Cellosaurus MM253c1-3D (CVCL_UM70)

Cross-references
Cell line name	MM253c1-3D
Accession	CVCL_UM70
Resource Identification Initiative	To cite this cell line use: MM253c1-3D (RRID:CVCL_UM70)
Comments	Selected for resistance to: ChEBI; CHEBI_4305; Dacarbazine (DTIC; (5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide)). Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (from parent cell line).
Disease	Amelanotic melanoma (NCIt: C3802)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_UM66 (MM253c1)
Sex of cell	Male
Age at sampling	46Y
Category	Cancer cell line
Publications	PubMed=7060019 Peter G. Parsons, Susan G. Smellie, Leanne E. Morrison, Ian P. Hayward; Properties of human melanoma cells resistant to 5-(3',3'-dimethyl-1-triazeno)imidazole-4-carboxamide and other methylating agents. Cancer Res. 42:1454-1461(1982) PubMed=6534346; DOI=10.1038/icb.1984.57 Ian P. Hayward, Peter G. Parsons; Epigenetic effects of the methylating agent 5-(3-methyl-1-triazeno) imidazole-4-carboxamide in human melanoma cells. Aust. J. Exp. Biol. Med. Sci. 62:597-606(1984) PubMed=6690060 Ian P. Hayward, Peter G. Parsons; Comparison of virus reactivation, DNA base damage, and cell cycle effects in autologous human melanoma cells resistant to methylating agents. Cancer Res. 44:55-58(1984) PubMed=4059365; DOI=10.1111/j.1751-1097.1985.tb08944.x Peter G. Parsons, Ian P. Hayward; Inhibition of DNA repair synthesis by sunlight. Photochem. Photobiol. 42:287-293(1985)
Cell line databases/resources	cancercelllines; CVCL_UM70
Encyclopedic resources	Wikidata; Q95990209
Entry history
Entry creation	25-Feb-2019
Last entry update	10-Apr-2025
Version number	9