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Cellosaurus SH-SY5Y-TrkB, clone BR6 (CVCL_UJ95)

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Cell line name SH-SY5Y-TrkB, clone BR6
Synonyms SY5Y-TrkB, clone BR6; SH-SY5Y-TrkB, BR6
Accession CVCL_UJ95
Resource Identification Initiative To cite this cell line use: SH-SY5Y-TrkB, clone BR6 (RRID:CVCL_UJ95)
Comments Population: Caucasian.
Doubling time: 18-24 hours (Kerafast=ECP007).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:8032; NTRK2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0019 (SH-SY5Y)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
Publications

PubMed=25684664; DOI=10.1016/j.canlet.2015.02.011; PMCID=PMC4361245
Radhika Iyer, Jamie L. Croucher, Michael Chorny, Jennifer L. Mangino, Ivan S. Alferiev, Robert J. Levy, Venkatadri Kolla, Garrett M. Brodeur;
Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma.
Cancer Lett. 360:205-212(2015)

PubMed=26797418; DOI=10.1016/j.canlet.2016.01.018; PMCID=PMC4792275
Radhika Iyer, Lea Wehrmann, Rebecca L. Golden, Koumudi Naraparaju, Jamie L. Croucher, Suzanne P. MacFarland, Peng Guan, Venkatadri Kolla, Ge Wei, Nicholas Cam, Gang Li ...Show all 13 authors... , Zachary Hornby, Garrett M. Brodeur; Show fewer authors
Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model.
Cancer Lett. 372:179-186(2016)

Cross-references
Cell line collections (Providers) Kerafast; ECP007
Cell line databases/resources cancercelllines; CVCL_UJ95
Encyclopedic resources Wikidata; Q98132490
Entry history
Entry creation25-Feb-2019
Last entry update14-Aug-2025
Version number12