Cellosaurus cell line ICGi008-A (CVCL

Cellosaurus ICGi008-A (CVCL_UJ81)

Cross-references
Cell line name	ICGi008-A
Synonyms	m55Alz-9L
Accession	CVCL_UJ81
Resource Identification Initiative	To cite this cell line use: ICGi008-A (RRID:CVCL_UJ81)
Comments	From: The Federal Research Center Institute of Cytology and Genetics; Novosibirsk; Russia. Population: Caucasian. Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:620; APP; Simple; p.Val717Ile (c.2149G>A); ClinVar=VCV000018088; Zygosity=Heterozygous (PubMed=30851551).
Disease	Alzheimer's disease (NCIt: C2866) Early-onset autosomal dominant Alzheimer disease (ORDO: Orphanet_1020)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_UJ82 ! ICGi008-B
Sex of cell	Male
Age at sampling	55Y
Category	Induced pluripotent stem cell
Publications	PubMed=30851551; DOI=10.1016/j.scr.2019.101415 Elena V. Grigor'eva, Tuyana B. Malankhanova, Elizaveta I. Ustyantseva, Julia M. Minina, Olga E. Redina, Vitaly V. Morozov, Andrey Ivanovich Shevela, Suren Minasovich Zakian, Sergey P. Medvedev; Generation of two iPSC lines (ICGi008-A and ICGi008-B) from skin fibroblasts of a patient with early-onset Alzheimer's disease caused by London familial APP mutation (V717I). Stem Cell Res. 36:101415-101415(2019)
Cell line databases/resources	hPSCreg; ICGi008-A
Biological sample resources	BioSamples; SAMEA5341576
Encyclopedic resources	Wikidata; Q94313420
Entry history
Entry creation	25-Feb-2019
Last entry update	19-Dec-2024
Version number	10