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Cellosaurus HCC78-TR (CVCL_UJ33)

[Text version]
Cell line name HCC78-TR
Accession CVCL_UJ33
Resource Identification Initiative To cite this cell line use: HCC78-TR (RRID:CVCL_UJ33)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_91338; 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine (TAE684).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:10261; ROS1 + HGNC; HGNC:11020; SLC34A2; Name(s)=SLC34A2-ROS1 (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg58Ter (c.172C>T) (p.Pro72Leu, c.215C>T); ClinVar=VCV000376310; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser241Phe (c.722C>T); ClinVar=VCV000012359; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2061 (HCC78)
Sex of cell Male
Age at sampling 65Y
Category Cancer cell line
Publications

PubMed=24349229; DOI=10.1371/journal.pone.0082236; PMCID=PMC3862576
Kurtis D. Davies, Sakshi Mahale, David P. Astling, Dara L. Aisner, Anh T. Le, Trista K. Hinz, Aria Vaishnavi, Paul A. Bunn Jr., Lynn E. Heasley, Aik-Choon Tan, David Ross Camidge ...Show all 13 authors... , Marileila Varella-Garcia, Robert C. Doebele; Show fewer authors
Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer.
PLoS ONE 8:e82236.1-e82236.13(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UJ33
Encyclopedic resources Wikidata; Q93983894
Entry history
Entry creation25-Feb-2019
Last entry update19-Dec-2024
Version number12