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Cellosaurus BT-549-Dox (CVCL_UJ22)

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Cell line name BT-549-Dox
Accession CVCL_UJ22
Resource Identification Initiative To cite this cell line use: BT-549-Dox (RRID:CVCL_UJ22)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Misspelling: HTB-122-Dox; Note=Based on the ATCC catalog number of the parent cell line.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Gene fusion; HGNC; HGNC:2092; CLTC + HGNC; HGNC:29559; VMP1; Name(s)=CLTC-VMP1 (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Val275fs*1 (c.821delG) (p.W274fs); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; c.265_607del343; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Ser (c.747G>C); ClinVar=VCV000406598; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1092 (BT-549)
Sex of cell Female
Age at sampling 72Y
Category Cancer cell line
Publications

PubMed=7902062
Manuel de la Torre, Xiao-Yong Hao, Rolf Larsson, Peter Nygren, Takashi Tsuruo, Bengt Mannervik, Jonas Bergh;
Characterization of four doxorubicin adapted human breast cancer cell lines with respect to chemotherapeutic drug sensitivity, drug resistance associated membrane proteins and glutathione transferases.
Anticancer Res. 13:1425-1430(1993)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UJ22
Encyclopedic resources Wikidata; Q93432704
Entry history
Entry creation25-Feb-2019
Last entry update19-Dec-2024
Version number12