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Cellosaurus AIP KO MEF (CVCL_UJ02)

[Text version]
Cell line name AIP KO MEF
Synonyms Aip-Null MEF; AIP Knock-out Fibroblasts
Accession CVCL_UJ02
Resource Identification Initiative To cite this cell line use: AIP KO MEF (RRID:CVCL_UJ02)
Comments Knockout cell: Method=Gene trap; MGI; MGI:109622; Aip.
Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:98834; Trp53 (Note=With p.Met1_Lys302del).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Sex of cell Sex unspecified
Age at sampling 12FD
Category Transformed cell line
Publications

PubMed=19850893; DOI=10.2353/ajpath.2009.081131; PMCID=PMC2789606
Heliovaara E., Raitila A., Launonen V., Paetau A., Arola J., Lehtonen H.J., Sane T., Weil R.J., Vierimaa O., Salmela P., Tuppurainen K., Makinen M., Aaltonen L.A., Karhu A.
The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas.
Am. J. Pathol. 175:2501-2507(2009)

PubMed=24662816; DOI=10.1038/onc.2014.50
Tuominen I., Heliovaara E., Raitila A., Rautiainen M.-R.I., Mehine M., Katainen R., Donner I., Aittomaki V., Lehtonen H.J., Ahlsten M., Kivipelto L., Schalin-Jantti C., Arola J., Hautaniemi S., Karhu A.
AIP inactivation leads to pituitary tumorigenesis through defective Galphai-cAMP signaling.
Oncogene 34:1174-1184(2015)

Cross-references
Cell line collections (Providers) ATCC; CRL-3288
Encyclopedic resources Wikidata; Q93323928
Entry history
Entry creation25-Feb-2019
Last entry update10-Sep-2024
Version number8