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Cellosaurus AIP KO MEF (CVCL_UJ02)

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Cell line name AIP KO MEF
Synonyms Aip-Null MEF; AIP Knock-out Fibroblasts
Accession CVCL_UJ02
Resource Identification Initiative To cite this cell line use: AIP KO MEF (RRID:CVCL_UJ02)
Comments Knockout cell: Method=Gene trap; MGI; MGI:109622; Aip.
Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:98834; Trp53 (Note=With p.Met1_Lys302del).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Sex of cell Sex unspecified
Age at sampling 12FD
Category Transformed cell line
Publications

PubMed=19850893; DOI=10.2353/ajpath.2009.081131; PMCID=PMC2789606
Elina Heliovaara, Anniina Raitila, Virpi Launonen, Anders Paetau, Johanna Arola, Heli J. Lehtonen, Timo Sane, Robert J. Weil, Outi Vierimaa, Pasi Salmela, Karoliina Tuppurainen ...Show all 14 authors... , Markus Makinen, Lauri Antti Aaltonen, Auli Karhu; Show fewer authors
The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas.
Am. J. Pathol. 175:2501-2507(2009)

PubMed=24662816; DOI=10.1038/onc.2014.50
Iina Tuominen, Elina Heliovaara, Anniina Raitila, Marja-Riitta Inkeri Rautiainen, Miika Mehine, Riku Katainen, Iikki Donner, Viljami Aittomaki, Heli J. Lehtonen, Manuel Ahlsten, Leena Kivipelto ...Show all 15 authors... , Camilla Schalin-Jantti, Johanna Arola, Sampsa Hautaniemi, Auli Karhu; Show fewer authors
AIP inactivation leads to pituitary tumorigenesis through defective Galphai-cAMP signaling.
Oncogene 34:1174-1184(2015)

Cross-references
Cell line collections (Providers) ATCC; CRL-3288
Encyclopedic resources Wikidata; Q93323928
Entry history
Entry creation25-Feb-2019
Last entry update14-Aug-2025
Version number9