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Cellosaurus OVCAR-5-CisR (CVCL_UI87)

[Text version]
Cell line name OVCAR-5-CisR
Synonyms OVCAR5-CisR
Accession CVCL_UI87
Resource Identification Initiative To cite this cell line use: OVCAR-5-CisR (RRID:CVCL_UI87)
Comments Problematic cell line: Possibly misclassified. Parent cell line (OVCAR-5) was originally thought to be a high grade ovarian serous adenocarcinoma but suspected to have a upper gastrointestinal origin.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Omics: Genome sequenced.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1628 (OVCAR-5)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): PubMed=30485824

Markers:
AmelogeninX
CSF1PO10
D5S81811,13
D7S82010
D13S31710,13
D16S53911
D21S1131
TH017,9.3
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=21372221; DOI=10.1158/1078-0432.CCR-10-2289
Santiskulvong C., Konecny G.E., Fekete M., Chen K.-Y.M., Karam A., Mulholland D., Eng C., Wu H., Song M., Dorigo O.
Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma.
Clin. Cancer Res. 17:2373-2384(2011)

PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096
Papp E., Hallberg D., Konecny G.E., Bruhm D.C., Adleff V., Noe M., Kagiampakis I., Palsgrove D., Conklin D., Kinose Y., White J.R., Press M.F., Drapkin R.I., Easwaran H., Baylin S.B., Slamon D.J., Velculescu V.E., Scharpf R.B.
Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.
Cell Rep. 25:2617-2633(2018)

Cross-references
Encyclopedic resources Wikidata; Q98128407
Entry history
Entry creation25-Feb-2019
Last entry update21-Mar-2023
Version number7