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Cellosaurus OVCAR-5-CisR (CVCL_UI87)

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Cell line name OVCAR-5-CisR
Synonyms OVCAR5-CisR
Accession CVCL_UI87
Resource Identification Initiative To cite this cell line use: OVCAR-5-CisR (RRID:CVCL_UI87)
Comments Problematic cell line: Possibly misclassified. Parent cell line (OVCAR-5) was originally thought to be a high grade ovarian serous adenocarcinoma but suspected to have a upper gastrointestinal origin.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Omics: Genomics; Whole genome sequencing.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1628 (OVCAR-5)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): PubMed=30485824

Markers:
AmelogeninX
CSF1PO10
D5S81811,13
D7S82010
D13S31710,13
D16S53911
D21S1131
TH017,9.3
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=21372221; DOI=10.1158/1078-0432.CCR-10-2289; PMCID=PMC3078990
Chintda Santiskulvong, Gottfried E. Konecny, Mirela Fekete, Kuang-Yui Michael Chen, Amer Karam, David Mulholland, Carol Eng, Hong Wu, Min Song, Oliver Dorigo;
Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma.
Clin. Cancer Res. 17:2373-2384(2011)

PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096; PMCID=PMC6481945
Eniko Papp, Dorothy Hallberg, Gottfried E. Konecny, Daniel C. Bruhm, Vilmos Adleff, Michael Noe, Ioannis Kagiampakis, Doreen Palsgrove, Dylan Conklin, Yasuto Kinose, James R. White ...Show all 18 authors... , Michael Frederick Press, Ronny I. Drapkin, Hariharan Easwaran, Stephen Bruce Baylin, Dennis Joseph Slamon, Victor E. Velculescu, Robert B. Scharpf; Show fewer authors
Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.
Cell Rep. 25:2617-2633(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UI87
Encyclopedic resources Wikidata; Q98128407
Entry history
Entry creation25-Feb-2019
Last entry update10-Apr-2025
Version number11