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Cellosaurus hTERT NF1 ipNF03.3 (CVCL_UI77)

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Cell line name hTERT NF1 ipNF03.3
Synonyms ipNF03.3
Accession CVCL_UI77
Resource Identification Initiative To cite this cell line use: hTERT NF1 ipNF03.3 (RRID:CVCL_UI77)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Caution: ABM wrongly indicates that this cell line originates from a female donor (ABM=T0193).
Derived from site: In situ; Peripheral nervous system, nerve; UBERON=UBERON_0001021.
Cell type: Schwann cell; CL=CL_0002573.
Sequence variations
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Lys1423Lys (c.4269G>A); ClinVar=VCV000423536; Zygosity=Heterozygous; Note=Exon skipping mutation. Germline (PubMed=27617404).
Disease Neurofibromatosis type 1 (NCIt: C3273)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Telomerase immortalized cell line
Publications

PubMed=27617404; DOI=10.1038/labinvest.2016.88
Hua Li, Lung-Ji Chang, Debbie R. Neubauer, David F. Muir 4th, Margaret R. Wallace;
Immortalization of human normal and NF1 neurofibroma Schwann cells.
Lab. Invest. 96:1105-1115(2016)

Cross-references
Cell line collections (Providers) ABM; T0193
Encyclopedic resources Wikidata; Q94305815
Entry history
Entry creation25-Feb-2019
Last entry update14-Aug-2025
Version number13