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Cellosaurus U-HO1-PTPN1 (CVCL_UI40)

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Cell line name U-HO1-PTPN1
Accession CVCL_UI40
Resource Identification Initiative To cite this cell line use: U-HO1-PTPN1 (RRID:CVCL_UI40)
Comments Doubling time: ~14 days (PubMed=21144060).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:9642; PTPN1.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:9642; PTPN1; Unexplicit; Ex2-8del; Zygosity=Unspecified (CelloPub=CLPUB00457).
Disease Hodgkin lymphoma (NCIt: C9357)
Hodgkin lymphoma (ORDO: Orphanet_98293)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2220 (U-HO1)
Sex of cell Male
Age at sampling 23Y
Category Cancer cell line
Publications

CLPUB00457
Silke Wegener, Andreas Mader, Ingo Melzner, Silke Bruderlein, Peter Moller;
Lack of PTPN1 (PTP1B) in U-HO1, a new Hodgkin-derived cell line, protects cells from apoptosis.
Haematologica 92 Suppl. 5:39-39(2007)

PubMed=21144060; DOI=10.1186/1471-2121-11-99; PMCID=PMC3018409
Hans Knecht, Silke Bruderlein, Silke Wegener, Daniel Lichtensztejn, Zelda Lichtensztejn, Bruno Lemieux, Peter Moller, Sabine Mai;
3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including 't-stumps'.
BMC Cell Biol. 11:99.1-99.10(2010)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM01913
Encyclopedic resources Wikidata; Q98133718
Entry history
Entry creation25-Feb-2019
Last entry update27-Nov-2025
Version number10